Legend states that it originated in the 1st century, but the first documentary record of it dates to 1088, at which time it was outside the city walls.
For a time at the end of the 14th century it housed Dominican nuns after the destruction of their monastery outside the walls - they later built and moved to the nearby San Mattia complex.
The church was rebuilt between 1624 and 1633 to designs by Pietro Fiorini, including a side portico and a new internal layout.
Luigi Marchesini (1796-1882) radically altered the church, adding two side aisles to the nave, a cupola and a large chapel as well as rebuilding the facade in Neoclassical fashion as a side portico.
This article about a church building or other Christian place of worship in Italy is a stub.