She grew up in Nice in a family of artists, with an American mother, the singer of the group Daisy Duck in the early 1980s,[1][2] and an architect father who studied fine arts.

[3] In 2009, Santa founded the group Hyphen Hyphen with her childhood friends Adam (Romain Adamo), Line (Laura Christin) and Zac (Zaccharie Schütte) and with whom, in 2016, she won the Victoire de la musique Révélation scène [fr].

[8] On 14 July 2023,[9] she gave a performance in Brussels, giving a solo concert with her grand piano suspended 40 metres above the ground, as part of the opening of the inaugural Urban Garden de Plaisirs d'Été organised by the city of Brussels.

[10][11][12] She joined the Enfoirés 2024 troupe where Popcorn salé was performed on stage at the Arkéa Arena in Bordeaux.

[13][14] On 8 September 2024, she opened the 2024 Summer Paralympics closing ceremony at the Stade de France in front of 60,000 spectators by performing Vivre pour le Meilleur [fr] by Johnny Hallyday.