Santa Clara is a city in Guadalupe County, Texas, United States.

[5] Santa Clara is located in western Guadalupe County.

According to the United States Census Bureau, Santa Clara has a total area of 2.4 square miles (6.3 km2), all land.

12.1% of all households were made up of individuals, and 4.0% had someone living alone who was 65 years of age or older.

Santa Clara is served by the Marion Independent School District.