Neighboring barangays include Mariblo, Paraiso, Paltok, Talayan, Sto.

Domingo, Paligsahan, West and South Triangles under the first and fourth Legislative districts in Quezon City, Metro Manila, Philippines.

Fisher Mall, the former Pantranco bus terminal site, is located at the corner of Roosevelt and Quezon Avenues, while Halili School of Ballet and Phoenix Publishing House are found along Quezon Avenue.

Heroes Hill, encompassing more than three-fourths (3/4) of the entire barangay, is a closed gated community developed by Trans-American Sales and Exposition for former American soldiers in the Philippine-American War.

As of the 2015 census of the National Statistics Office (Philippines), the population of Santa Cruz is 4,784.