Santa Fe is an unincorporated community in southeastern Monroe County, Missouri, United States.
[1] It is located approximately twenty-five miles north of Mexico, near the southern edge of Mark Twain Lake.
[4] The Mark Twain State Park Picnic Shelter at Buzzard's Roost was listed on the National Register of Historic Places in 1985.
A battle was fought on July 24, 1862, in Santa Fe during the American Civil War between the 3rd Iowa Volunteer Cavalry Regiment, under command of Colonel Henry Clay Caldwell, and the 1st Northeast Missouri Cavalry led by Colonel Joseph C. Porter.
In A History of Northeast Missouri, Volume 1 the writer indicates this battle might have taken place on July 22, as by the 23rd Porter had already supposedly entered Callaway County.