On July 22, 1862, fifteen Daughters of Charity of Saint Vincent de Paul arrived in the Philippines from Spain.

The college was then in Intramuros until World War II when it was totally destroyed by shelling and fire in the liberation of Manila.

After losing the Colegio, the sisters sought refuge at St. Rita's College which was fortunately spared from the ravages of war.

Just after the Vietnam War, Santa Isabel College opened the Center for Assistance to Displaced Persons.

The refugees and boat people from Vietnam, Laos and Cambodia were assisted by the Center under the sisters and staff.

The Louise de Marillac Foundation, Inc. caters to the needs of an adopted community in Paliparan, Dasmariñas, Cavite and in Barangay 736, Zone 80, Quirino Avenue, Manila.

Santa Isabel College then is the only school in the Philippines offering Bachelor of Science in public relations.

After the PAASCU visit last February 27–28, 2000, the school was granted reaccreditation for a period of five years, effective April 2002 – 2007.

Santa Isabel College undertook intensive curriculum revision, realigning and mapping for more cohesive and relevant offerings.

The school year 2005-2006 ushered in new programs: Bachelor of Science in hotel and restaurant management and evening classes for working students.

The practicum center serves as the in-house training ground of the hotel and restaurant management students.

Eventually, the internet café became part of the facilities of Chateau Santa Isabel Practicum Center which was opened on May 1, 2005.

The Higher Education Department passed the Level 2 PAASCU Accreditation on January 25, 2005, during the Interim Visit.

The school instills in the young, benevolent love, humility, and self-control in relation to themselves, their peers, and specially the less-privileged.

She provided free education to the orphaned daughters of the Spanish soldiers and later to deserving Filipino young girls.