First records of a "hospitale" in Mirandola dates back to 1311, in a document which also mentions two branches in Tiramuschio (today Tramuschio) and Borgo Bonaga (later called Borgofuro or Borgonovo).

The Sacred Hospice of Santa Maria Bianca was founded in 1432 by the Confraternity of the Misericordia dei Battuti, with the aim of "collecting and maintaining the exposed, housing pilgrims and caring for the poor, sick and insane".

After a few years the hospice was enlarged thanks to the considerable inheritance of 550 pounds of bolognini left in 1448 by the nobleman Francesco, son of Antonio Padella of the Manfredi family.

According to a document dated 13 May 1574, drawn up during the pastoral visit of Eustachio Locatelli, bishop of Reggio Emilia, the Mirandola confraternity annually elected a godfather and two massari, who supervised and administered the hospital.

The hospital was transferred to the former Jesuit monastery in 1785, while the old building was first entrusted to the mendicant order and then housed the Royal Magistrate's Court of Mirandola and the prisons.

The old building with its porticoes and the deconsecrated church of Santa Maria dei Battuti have been lost, having been demolished during the Fascist era for the construction of the Palazzo della Milizia in the 1930s.

From 1859 to 1866, during the Third Italian War of Independence, the hospital treated many sick soldiers, either stationed there or passing through (at that time the nearby town of Poggio Rusco was still under Austrian rule of the Kingdom of Lombardy–Venetia and the front line was about ten kilometres north of Mirandola).

At the beginning of the 20th century, it was decided to build a new hospital, partly thanks to a large donation bequeathed by the engineer Pietro Tosatti (1846-1905), outside the former city walls.

The work was completed in less than two years and on 11 October 1908 the Santa Maria Bianca hospital was finally transferred to the new complex, in a large green area to the south-west of the city centre, where it still stands today.

On 23 April 1994, after 18 months of work (costing a total of 20.3 billion lire at the time), the so-called Single Hospital of the Northern Modena area was inaugurated.