Santa Maria Regina Coeli ('Saint Mary the Queen of Heaven') is a Roman Catholic church in central Naples, Italy.

In 1812, the nuns were transferred to the Monastery of Gesù e Maria and in their place moved in the Sisters of Charity of Saint Jeanne-Antide Thouret.

The entrance is preceded by two staircases leading to a pronaos with arcades, which was frescoed (1594) by the Flemish painter Loise Croys, pupil of Paul Bril.

The cloister has a bust of San Vincenzo de' Paoli and by Santa Giovanna Antida Thouret.

Reconstructions were carried out in 1599, and further work in the convent occurred in the second half of the 17th century by the architect Francesco Antonio Picchiatti.