Santa Maria degli Angeli Crucifixion

The Santa Maria degli Angeli Crucifixion is a fresco lunette by Andrea del Castagno, created c. 1455.

Is is held in the Museo del Cenacolo di Sant'Apollonia, in Florence.

It was originally sited in the cloister of the monastery of Santa Maria degli Angeli, Florence, where several authors wrote of seeing it, including the anonymous Gaddiano and Vasari, with the latter mentioning it in both editions of his Lives of the Artists as "at the top of cloister over the garden".

Giuseppe Richa wrote that it was rediscovered by a Camaldolese monk of the monastery.

Its dating is uncertain – Salmi and Horster place it late in his career, which is the majority opinion.