In 2016 the island was sold to a private company from Treviso, Giesse Investimenti s.r.l., to host a new resort.
Santa Maria della Grazia rose during the Middle Ages in the place where Venice’s rubble was discarded.
The island takes its name from a supposedly miraculous Madonna which was on display in its former church.
During the Napoleonic period the convent was suppressed and changed to a powder-magazine, which in 1849 exploded destroying both the ex-convent and the church.
The island was the site of an infectious diseases hospital until the end of the twentieth century.