Santa Maria di Monteverginella is a Roman Catholic church in Naples, Italy.

The building and adjacent monastery was founded in 1314 by the resident of the neighborhood, Bartolomeo di Capua, who was also protonotary of the King Robert of Anjou.

The aedicule or ancient shrine of Santa Maria di Alto Spirito was incorporated into the church.

In 1588, the complex underwent a partial remodeling by the architect and engineer Vito Alfieri and in the 17th century by Francesco Antonio Picchiatti.

The main altar was constructed of polychrome marble and pietra dure (1656) by Dionisio Lazzari.