It is located in the Rione Regola, at the intersection of alleyway of Via della Barchetta and the narrow Via di Monserrato, with the facade on the latter street, about three blocks northwest of the Palazzo Farnese.

[2] Santa Maria in Monserrato degli Spagnoli was founded in 1506 when the Brotherhood of the Virgin of Montserrat in Catalonia built a hospice for Spanish pilgrims.

San Giacomo degli Spagnoli was in poor repair, and many of the furnishings and artworks were transferred to Santa Maria in Monserrato, which is now the Spanish national church.

Construction was interrupted due to lack of funds, but the work proceeded over centuries under the direction, among others, of Bernardino Valperga and Francesco da Volterra.

In the niches above the lateral doors are statues of two Aragonese saints (1816), St. Isabel of Portugal and St. Peter Arbués, by the sculptor Juan Adán.

[7] The first chapel on the right, dedicated to San Diego de Alcalá, contains a burial plaque of Cardinal Bernardino Rocci (died 1599) on the pavement with his heraldic shield on the ceiling.

[5] At the right is the mausoleum of two popes from the Spanish Borgia family, Callixtus III (1455-1458) and Alexander VI (1492-1503), sculpted by Felipe Moratilla, and completed only in 1889.

The rich polychrome marble decoration completed in the 18th century by Antonio Francés and Miguel de Cetina, based on designs by a canon from Barcelona, Francisco Gómez García, (died 1778).

On the right wall, stands the Neoclassical monument to the former Spanish ambassador José Narciso Aparici Soler, who died in Rome in 1845.

It contains a copy of the statue of St James by Jacopo Sansovino, commissioned by Cardinal Jaume Serra i Cau (died 1517) for his chapel in San Giacomo degli Spagnoli.