Following this, SR 126 as Telegraph Road encounters the community of Buckhorn, as well as the edge of Piru and the important historical Rancho Camulos.

[2] The stretch of SR 126 between Santa Paula and the Los Angeles County line has seen an unusually high amount of traffic fatalities and other injurious accidents.

Head-on collisions were very frequent on the older, curvy, two-laned sections, earning this portion of the road its nickname, "Blood Alley".

In the face of anti-development pressure from Ventura County citizens, and suffering from severe financial problems as a result of the 1971 Sylmar earthquake and the late-1970s California tax revolt, Caltrans abandoned its plans.

The freeway, which by then had reached Santa Paula, terminates at a four-way intersection immediately east of the city.

The 1984 Summer Olympics Organizing Committee was allowed to close the freeway portion between Ventura and Santa Paula for cycling practice for the 100 Kilometer Team Trials on two consecutive Thursdays.

In 2017, Caltrans began construction along the 1.75-mile (2.82 km) eastern end of SR 126, upgrading the 6-lane divided highway to an 8-lane freeway.

Except where prefixed with a letter, postmiles were measured on the road as it was in 1964, based on the alignment that existed at the time, and do not necessarily reflect current mileage.