[2] Sierra Highway begins at Tunnel Station within the northernmost limits of the City of Los Angeles, where it intersects with San Fernando Road.

[5] According to the City of Santa Clarita, Caltrans maintains Sierra Highway (14U) from 500 feet north of Newhall Avenue to Whispering Leaves Drive.

In 2018 Caltrans funded a new pedestrian overpass as one item on a list of requested improvements by the city before they accept relinquishment of the road from the state.

Upon exiting the mountains, Sierra Highway enters the Antelope Valley and serves as one of the main streets of Palmdale, Lancaster, and Rosamond.

Just shy of Mojave the freeway portion of Route 14 ends, while the frontage road becomes a dirt path and eventually terminates.

The highway cuts across Red Rock Canyon State Park to follow a series of valleys along the crest of the Sierra Nevada.

While in the Sierra Nevada, the road passes by attractions such as Mammoth Mountain, Yosemite National Park and Mono Lake.

El Camino Sierra separates from U.S. 395, just prior to the Nevada state line at Topaz Lake, following SR 89.

This book contained an article that sung the praises of this "soon-to-be-world-famous highway" called El Camino Sierra.

While noting that it was still mostly an unimproved trail, the article assured the readers that county and state officials were working frantically to upgrade the route and, with the aid of convict labor, this would soon be a "boulevard the entire distance from Los Angeles to Lake Tahoe."

[12] The Los Angeles Times declared El Camino Sierra complete on February 19, 1931, announcing that the portion from Mojave to Owens Valley was now paved, and would be dedicated the following Sunday.

The southern terminus of U.S. 395 was extended from Spokane, Washington to San Diego, using El Camino Sierra from near what is now Topaz Lake to Inyokern, by 1935.

By 1937, U.S. Route 6 was extended from Colorado, mostly along the Midland Trail, to Long Beach using El Camino Sierra south of Bishop.

The owner of one such truck has driven it along Sierra Highway for nostalgia, enjoying the terrified looks received from passing motorists who recognize it.