The Santa Rita Fault (Spanish: Falla de Santa Rita) is a strike-slip fault in the department of Antioquia in northern Colombia.

The fault has a total length of 81.0 kilometres (50.3 mi) and runs along an average north to south strike of 010.6 ± 6 in the Central Ranges of the Colombian Andes.

The trace is characterized by linear valleys, strong breaks in slope, offset alluvial fans and colluvial deposits, and local subsidence of the soil.

The Santa Rita Fault might be the source of a historic magnitude 4.8 earthquake.

[2] Gómez Tapias, Jorge; Montes Ramírez, Nohora E.; Almanza Meléndez, María F.; Alcárcel Gutiérrez, Fernando A.; Madrid Montoya, César A.; Diederix, Hans (2015).