Santa Sofia is the oldest Roman Catholic church structure in the city of Padua, region of Veneto, Italy.

The structure underwent embellishment near the end of the fourteenth century to meet the liturgical reforms approved by the Council of Trent.

[1] A seventeen-year-old Andrea Mantegna painted his first independent work for this church, an altarpiece depicting Madonna with Child in conversation with saints.

[1] The north range of the upper part of the facade has sunken, due to a failure of the foundation took place around the time of construction.

Characterized by niches, blind arcades and hanging arches, it is linked perhaps to the construction site of Torcello and is dated to the first half of the twelfth century.

The mullioned window at the top is from the twentieth-century restoration while the large oculus is fourteenth century, the result of Bishop Stephen from Carrara to adorn the structure.

It returned the building to a severe appearance and with harmonious embellishments previously distorted by the sixteenth and seventeenth centuries.

Opposite, on the left aisle, altar with very valuable Pietà of Egidio from Wiener Neustadt on the vaults are continuing with Gothic frescoes.

[1] The complex apse is surrounded by niches-seat converging to central niche that bears, on the arch, a fourteenth-century fresco with the Virgin Enthroned with Saints.