A large open-air amphitheater divides the classroom complex, and the school's MUR, music, stagecraft, film and broadcasting workshops, and Black Box Theater.

The technical, 422-seat Performing Arts Center, dance studios, and the student parking lot are located west of the multipurpose room.

Santa Susana's school structure is the "school-within-a-school" model, which allows students to pursue their academic interests as they build skills for a post-secondary life.

The World Languages course of study integrates the Career Education standards in Hospitality, Tourism, and Recreation and is conducted in French, German, or Spanish.

[citation needed] Advanced Placement courses offered include: AP English Language & Literature, Calculus AB and BC, Chemistry, Computer Science, Environmental Science, French, Music Theory, 2D Design; 2D Studio Art: Drawing, World and U.S. History, Physics 1, 2, & C - E & M, and C-Mechanics; Psychology, Statistics, Government/Economics and Human Geography.

In 2007 Santa Susana received a large California Department of Education Specialized Secondary Programs Grant, to create the Academy of Law & Society.

Students in this program are mentored by several attorney coaches, college Mock Trial team members, and an Artist in Residence.

The Distinguished Speaker series brings academic topics into the theater and has included guests such as but not limited to Holocaust Survivor Ben Lesser, Curiosity Rover engineer Melissa Soriano, Congressional Medal of Honor Recipient Sergeant Gary Littrell, Skeptic Magazine Editor Michael Shermer, and Former Mexican President Vicente Fox.

First approved by voters in 2004 as part of the Simi Valley Unified School District's C4 Bond measure, HMC Architects initially delivered plans for a multipurpose room for which $8.6 million was allocated.

Students receive an articulated curriculum and work-based learning experiences such as guest speakers, trips to job sites, and mentor & internships.

Students work on projects that range from coding rock-paper-scissors in JavaScript and PHP with a database, to redoing local restaurant or business sites, to creating and maintaining the school's website.

[8] The Stagecraft Technology class is a member of the Career Education Center administered by the Ventura County Superintendent of Schools and taught by professionals who continue to work in the entertainment industry.

Each student is afforded a chance to focus in on his or her area of interest, with an eye toward eventual placement in a professional internship and job.

“Battle for Milquarious, White Gold Milkdonkulous Giveaway.” The contest was designed to encourage teens to get creative with their video-making skills for a chance to win thousands of dollars for their public high schools’ art programs.

[18][19][20] In March 2016, two of Santa Susana High School's choirs were selected to perform at the funeral of former First Lady of the United States Nancy Reagan.