Santa Trinita (pronounced [ˈsanta ˈtriːnita]; Italian for "Holy Trinity") is a Roman Catholic church located in front of the piazza of the same name, traversed by Via de' Tornabuoni, in central Florence, Tuscany, Italy.

South on Via de' Tornabuoni is the Ponte Santa Trinita over the river Arno; across the street is the Palazzo Spini Feroni.

The church was founded by the Vallombrosians in the 11th century (when it was outside the city walls), and subsequently patronized by many of Florence's wealthiest families.

The Column of Justice (Colonna di Giustizia) in the piazza outside, originates from the Baths of Caracalla in Rome, and was a gift to Cosimo I de' Medici by Pope Pius IV.

Francesco Sassetti had been a manager of the Medici Bank,[4] and some of the Ghirlandaio frescoes capture views of contemporary Florence.