Santa Ysabel (Spanish for "St. Elizabeth") is an unincorporated community in the Santa Ysabel Valley of eastern San Diego County, California.

The 1818 Santa Ysabel Asistencia is located here, a Spanish mission asistencia (sub-mission) of Mission San Diego de Alcalá.

The town site is within the former Rancho Santa Ysabel, an 1844 Mexican land grant to José Joaquín Ortega and Eduardo Stokes.

Other notable sights of the small town include the famous Dudley's Bakery and the Julian Apple Pie factory.

This San Diego County, California–related article is a stub.