U.S. Route 6 passes through Santaquin as Main Street and leads west 24 miles (39 km) to Silver City.

Utah State Route 198 leads north from I-15 5 miles (8 km) to Payson.

According to the United States Census Bureau, Santaquin has a total area of 10.4 square miles (26.9 km2), of which 0.3 acres (1,204 m2), or 0.01%, are water.

Santaquin, one of the early settlements along the Salt Lake Road, was originally settled in late 1851.

In 1856 it was renamed "Santaquin" for the son of Guffich, a local native chieftain friendly to the settlers.

[7] Santaquin incorporated as a town in the 1890s and changed to a city effective January 4, 1932.

[11] Orchard Days is a week-long celebration in late July and early August with a multitude of activities including a parade, rodeo, carnival, scavenger hunt, and several other family-friendly activities.