He marked his debut in a 2004 Malayalam movie, Two Wheeler and played the main antagonist in Mayavi.

Jogi was born in Eravimangalam to Purathu Sethumadhavan and Komattil Malathi Amma.

He married Jijy on 24 June 2001 and had two daughters, Chithralekha and Kapila.

[1] Santhosh Jogi was found dead in his friend's flat at Thrissur on 13 April 2010.

His body was found hanging from a fan, and the police stated that the suicide was due to family problems.