Santhosh made his directorial debut with Gaddam Gang, the Telugu remake of the Tamil film Soodhu Kavvum (2013).
[2] Santhosh Jayakumar directed the privacy art Iruttu Araiyil Murattu Kuththu (2018) with Gautham Karthik again.
The success of the film prompted him to direct the Telugu remake Chikati Gadilo Chithakotudu (2019) and begin production on a sequel titled Irandam Kuththu starring himself.
[2][3][4][5][6] In 2018, he briefly began working on a film titled Theemai Dhaan Vellum with Gautham Karthik, but the film was later dropped.
[7] His upcoming film includes a thriller Pulanaivu with Arvind Swami.