Santi Matteo e Margherita is a Catholic parish church in the frazione of Ortignano in the town of Ortignano Raggiolo, province of Arezzo, region of Tuscany, Italy.
The church is part of the Diocese of Arezzo-Cortona-Sansepolcro.
Originally solely dedicated to Santa Margherita, upon its elevation to parish in 1699, it was also dedicated to St Matthew.
The interior once housed paintings from the Sienese school, including a tempera altarpiece depicting a Madonna and Child with Saints by Giacomo Pacchiarotto, now in the Museo Diocesano of Arezzo.
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