Santiago Donovan Guzmán (born July 25, 1949) is a retired Dominican professional baseball player, a right-handed pitcher who appeared in 12 Major League games for the St. Louis Cardinals from 1969–1972.

The native of San Pedro de Macorís stood 6 feet 2 inches (1.88 m) tall and weighed 180 pounds (82 kg).

Guzmán broke into pro baseball as a teenage sensation in 1967 for the St. Petersburg Cardinals of the Class A Florida State League.

[1] Called up to the Cardinals near the end of the 1969 season, he made his debut September 30 as the starting pitcher in a 4–3 loss to the Philadelphia Phillies.

He spent the bulk of that season with the Cardinals' Tulsa Oilers Triple-A farm club, then hurled one more game for the Redbirds in September.