Santiago High School has been an AVID National Demonstration School since 2007 and an AVID Schoolwide Site of Distinction since 2016.

Santiago hosts a range of sports including tennis, basketball, baseball, football, soccer, swim, track and field, volleyball and cross country.

Practices take place every week with differing times and days depending on season, sport, and projected weather.

[citation needed] Santiago High School has a wide range of programs and electives for its students such as JROTC, band, choir, art, culinary, drama,avid, world languages, automechanic, robotics, engineering design, computer science, and more.

Most of these programs have associated events, clubs, or higher levels such as "AP" or "college articulation" or "1P" and "2P".