[1] The unclassified extinct Escoria language was spoken by indigenous peoples around present-day Santiago de Veraguas.

Santiago did not exist in 1606 when the Bishop of Panama, Don Antonio Calderon, wrote his account of the peoples who formed the Province of Veragua.

The Santa Fe (the oldest), San Pedro del Montijo, Atalaya, Nuestra Señora de Remedios and Alanje.

On 4 December of the same year in the city of Santiago has proclaimed the Independence of the Veraguas province of Spanish power.

Its position in the middle of the country has been used to its advantages, promoting the construction of important roads and bridges to connect the rest of the Veraguas province.

Different infrastructure projects, such as the improvement of the quality of roads and public spaces, including the burial of electric cables in Avenida Central, have been worked on in recent years.

It is a popular shopping area to buy clothes, medicine or food before visiting the most famous destinations in the province.