Santiago de la Puebla is a village and municipality in the province of Salamanca, western Spain, part of the autonomous community of Castile-Leon.

It is located 54 kilometres from the provincial capital city of Salamanca and has a population of 417 people.

The municipality covers an area of 53 km².

The economy is based primarily on agriculture and olive growing.

This article about a location in the province of Salamanca, Spain, is a stub.