Santibáñez de la Sierra is a village and municipality in the province of Salamanca, western Spain, part of the region of León, in the autonomous community of Castile and León.

It is located 67 kilometres from the provincial capital city of Salamanca and has a population of 249 people.

It lies 611 metres above sea level and the postal code is 37670.

The municipality is ruled by the Independent Highlander Group, created in the village.

This article about a location in the province of Salamanca, Spain, is a stub.