Santo Cristo (PSGC:[1]) is a Quezon City barangay located in North EDSA, a busy commercial area of shopping malls, transport hubs and office buildings.

Neighboring barangays include Bahay Toro in the north; Veterans Village in the South, Bungad in the southeast; Bagong Pag-asa in the east; Ramon Magsaysay in the west, and Alicia in the northwest under the first Legislative district of Quezon City, Metro Manila, Philippines.

As of 2020 census published by the Philippine Statistics Authority, the population of Barangay Santo Cristo is 25,783, a two-fold increase from 2015 due to the inclusion of residents of SMDC's high-rise condominium projects Grass Residences and Fern at the Grass Residences.

[2] Only The Annex building of SM North EDSA complex is located within the southern portion of the barangay, as well as SMDC's Grass Residences.

The new Barangay and SK Councils were elected in October 2023.