Santo Domingo Kesté is a town in Campeche, Mexico in the Champotón Municipality.

[3] There is an Awakatek community in Santo Domingo Kesté, and they speak the Qʼeqchiʼ language.

[4] [5] Chihua pumpkins, peanuts, common beans, sesame seeds, sweet potatoes, maize, cassava, and hibuscus are grown in Santo Domingo Kesté, with chihua pumpkins being the most important crop economically.

A group originating from Huehuetenango and Quiché in Guatemala chose to settle in a location they named Santo Domingo Kesté.

[6] In 2018, the National Institute of Indigenous Peoples held the first Meeting of Cultural Groups of Guatemalan Origin in Santo Domingo Kesté, in which four hundred people participated from nearby ejidos, as well as a delegation from Guatemala.