Santo Domingo Tlatayápam is a village and small municipality in Oaxaca in south-western Mexico.

The municipality covers an area of 12 km².

It is part of the Teposcolula District in the center of the Mixteca Region As of the 2010 census, the village had a population of 147 inhabitants, while the municipality had a total population of 153 inhabitants.

[1] It is the third-smallest municipality in Mexico in population (following Santa Magdalena Jicotlán and Santiago Tepetlapa, both also in Oaxaca).

This article about a location in the Mexican state of Oaxaca is a stub.