In the Heian period, Sanuki was famous for its associations with the Buddhist monk Kūkai as both his birthplace and the place of his early upbringing.
In the Muromachi period, the area came under the control of the Hosokawa clan, who were appointed as shugo by the Ashikaga shogunate.
The province was awarded by Hideyoshi to his general Ikoma Chikamasa, who made Takamatsu Castle his stronghold.
In the Edo period, Sanuki was divided into five areas; three han, tenryō territory under direct control of the Tokugawa shogunate and a part of Tsuyama Domain whose headquarters was on Honshū.
[3] Per the early Meiji period Kyudaka kyuryo Torishirabe-chō (旧高旧領取調帳), an official government assessment of the nation’s resources, the province had 395 villages with a total kokudaka of 293,628 koku.