Sanusha has a younger brother Sanoop Santhosh, who is a child artist, known for his acting in Philips and the Monkey Pen.

[5] After performing in television serials, Sanusha started her film career in 2000 at the age of 5 with the movie Dada Sahib.

[6] She became a star in Malayalam films as baby Sanusha giving stellar performances in Meesa Madhavan, Kaazhcha, Mampazhakkalam etc.

[citation needed] She won the Kerala State Film Award for Best Child Artist in 2004 for her performances in Kaazhcha and Soumyam.

[9] In the Malayalam movie, Kuttiyum Kolum Sanusha acted against the midget actor Guinness Pakru, the role gave her rave reviews.