Her father, Shmuel Ben-Artzi, was a Polish-born Israeli Jewish educator, author, poet and biblical scholar, who died in 2011 at the age of 96.

In the Israel Defense Forces, she was a psycho-technical evaluator in the Department of Behavioral Sciences of the Military Intelligence Directorate ("Aman").

[2] Netanyahu worked as a psychotechnical evaluator of gifted children at the Institute for Promoting Youth Creativity and Excellence headed by Dr. Erika Landau, and at a rehabilitation center of the Ministry of Labour.

[9] In January 2010, the family housekeeper sued Netanyahu in a labor court for withholding wages, unfair working conditions and verbal abuse.

[11] In February 2016, the Jerusalem Labor Court ruled in favor of plaintiff Meni Naftali, who claimed that Sara Netanyahu had created a hostile work environment and awarded him damages of NIS 170,000.

In 2015, reports surfaced that she had ordered catered meals and charged the government nearly $100,000 for the expenses when the Prime Minister's Office already employed a cook.

[14] On September 8, 2017, Attorney General Avichai Mandelblit announced that Netanyahu would be charged with ordering meals at the state’s expense without authorization.

[21] On 16 June 2019, Netanyahu signed a plea deal and was convicted of misusing state funds, with the more severe charge of fraud being dropped.