[a] She had a regular role as Kim on the short-lived ABC sitcom Malibu Country, and appeared in the main cast of the TV Land comedy series Impastor.

[3] Rue began her acting career at the age of nine, appearing in the 1988 film Rocket Gibraltar as Kevin Spacey's daughter.

[4] She starred in the comedy Grand, before going on to work on Phenom; Minor Adjustments; Zoe, Duncan, Jack & Jane; ER; The Division and Popular.

She has appeared in several films, including A Map of the World, Can't Hardly Wait, A Slipping Down Life, Idiocracy, Gypsy 83.

In 2006, Rue starred in the stage musical Little Egypt with French Stewart, Jenny O'Hara and Gregg Henry at the Matrix Theatre in Los Angeles.

She had a stint on the CBS sitcom The Big Bang Theory, playing Dr. Leonard Hofstadter's physician girlfriend Dr. Stephanie Barnett for three episodes.

[5][6] In October 2010, Rue joined the cast of Rules of Engagement in a recurring role as Brenda, Jeff and Audrey's surrogate.

[8] Rue starred in the ABC show Malibu Country as Reba McEntire's upbeat trophy wife neighbor, Kim Sallinger.