She went to St Aidan's Anglican Girls School, Brisbane in 1992 and then continued her study at Queensland University of Technology to be an accountant.

Clarke and Heidi Middleton started their fashion business with a stall of their own designs at 1999 London's Portobello Road Market.

[3] In 2014, Clarke left Sass & Bide after the company was being sold to one of the biggest Australian retailers, Myer.

This new label was dedicated for luxurious travel collection and produced in Australia, with some contribution from artisans around the world.

[5][6] Clarke was made a Member of the Order of Australia (AM) in the 2019 Queen's Birthday Honours in recognition of her significant service to the fashion industry, and to charitable organisations.