[1] She began making comics in 2006 when she was living at the Flux Factory artist collective in Queens, New York.

[8] In 2010, Glidden wrote and illustrated the graphic novel How to Understand Israel in 60 Days or Less, a full-length exploration of her 2007 trip.

From 2010 to 2012, Glidden was part of Pizza Island, a studio consisting of cartoonists Julia Wertz, Lisa Hanawalt, Domitille Collardey, Karen Sneider, Kate Beaton and Meredith Gran.

[12] In October 2016, Drawn & Quarterly published Glidden's Rolling Blackouts, the nonfiction story of her travels in 2010 through Turkey, Syria, and Iraq with a small team of journalists.

Rolling Blackouts won the 2017 Lynd Ward Prize for Graphic Novel of the Year, sponsored by Penn State University Libraries and administered by the Pennsylvania Center for the Book.