However, due to safety concerns following terrorist attacks in London, the final runway show was moved to Los Angeles.
The winner of cycle 5 was 19-year-old Nicole Linkletter from Grand Forks, North Dakota, with Nick Pace finishing as the runner-up.
Notable interviews included Coryn revealing the fact that her mother struggled with depression, Nicole getting on her knees, Bre admitting she rarely showered, Jayla stating she went against her whole religion (Jehovah's Witness), and a girl named Susanna that had breast cancer.
After moving into their new home, the contestants went to a party with celebrities and had to walk a runway, portraying different styles given to them by MC Nate Dogg.
Sarah, who was given size 10 shoes (she wears a seven) stumbled, while Kim, who didn't know how to put on makeup, was blown off by Ashley, despite being friends.
Sarah landed in the bottom two because she lost her confidence on the runway but it was Ashley who was eliminated because the judges felt that she was not a model and was just trying to get by as a pretty girl.
Cassandra was upset that Tyra chose a "Mia Farrow in Rosemary's Baby"–inspired look for her and cried as her long brown hair was cut.
Ebony was annoyed with her partner Lisa's antics on the shoot and struggled to produce a great photo while Cassandra was reluctant to let go of her beauty pageant training as she posed.
Tyra informed Cassandra that if she survived onto the next week, her hair would be cut even shorter to look more like Mia Farrow.
Additionally, the judges decided that Jayla's extensions were too heavy for her face and if she survived onto the next week, she would receive a shorter haircut as well.
Cassandra, Nicole, Coryn, Kim, Lisa, and Nik were declared the winners of the pairs and safe until the following week.
Their challenge was to walk on a runway and pose on a turning platform for Sue Wong, which Bre won.
In the end, Cassandra decided to quit the competition despite a huge and strong modeling potential and portfolio and being in the top three for photos for the first three weeks.
Former panel judge Janice Dickinson photographed the remaining contestants in the following plastic surgery-themed photoshoot with undergone beauty enhancements.
In the end, Bre was saved and Diane was eliminated due to lack of confidence and inability to own her curves.
The show implied that the talk was due to Lisa's actions and the concerns of the other girls around her drinking and breakdowns.
Later, they had a challenge where they had to complete a commercial shoot, photoshoot, and press interview, all advertising Secret deodorant, in the space of thirty minutes.
The undeclared prize was that the girl with the strongest photograph would have her picture run as an actual advertisement for the product in print media.
The judges agreed that Lisa had the strongest performance this week, but they chose Nicole's photo as the best one and selected it.
Nik's lack of focus and poor performance during her commercial landed her in the bottom two with Coryn who was eliminated because she could not overcome her melancholy demeanor.
They then went to a boot camp where they had to do all sorts of physical activities, including crawling in the mud, and then directly (without changing or showering) to a go-see with Elle Girl, a challenge which Lisa won, allowing her to meet and be taught by fashion stylist Todd Hallman.
They had to also impress Benny Medina by doing a storyboard on their lives, which Kim won and got to guest star in an episode of Veronica Mars.
Tyra shocked the contestants by announcing that both girls were "packing their bags," then revealed a picture of the Union Jack.
Both girls were still in the running to becoming the fifth winner of America's Next Top Model because everyone would be packing their bags to go to London.
The girls got a visit from Jenny Shimizu, which inspired Kim, as well as a lesson about image where they were shown bad pictures of themselves.
They then moved into Savoy Hotel as their loft for the remainder of the competition and later that night two English gentlemen took Bre and Nik out on a carriage in London.
For the shoot, the girls posed together in a phone booth with only underwear, their galoshes, and a newspaper to cover themselves, as if they had tried to flee from the paparazzi.
Later, the five remaining contestants then posed as modern interpretations of classical art in an advertisement for Quench body lotion by Olay.
Afterward, they had dinner at an Indian restaurant with Nigel who introduced them to his Sri Lankan mother and she showed them how to wear a sari properly.
While Bre was saved for the fourth time in the bottom two, Jayla was eliminated in her third-bottom two appearances because the judges felt that she no longer believed in herself and that she wasn't strong enough to survive in the cutthroat modeling industry.