Sergei Lukyani Lukashin (Armenian: Սարգիս Լուկյանի Լուկաշին; Russian: Сергей Лукьянович Лукашин, born Sargis Srapionyan (Սրապիոնյան); 1883 or 1885 – 1937) was an Armenian Bolshevik politician and Soviet statesman.

[2] He participated in the Bolsheviks' armed rebellion during the October Revolution, after which he fought on the Southern Front of the Russian Civil War in the Don region.

Between 1922 and 1925 was the Chairman of the Council of People's Commissars of the Armenian SSR (equivalent of a Prime Minister).

He oversaw the normalization of conditions and the first steps of industrialization in the Armenian SSR, which was suffering from a severe refugee crisis, famine, and disease in the early 1920s.

From 1925 to 1928 he was Vice Chairman of the Council of People's Commissars of the Transcaucasian SFSR and occupied various ministerial positions.