Sasabe (O'odham: Ṣaṣawk) is a small hamlet in the Altar Valley of southern Pima County, Arizona, United States, immediately north of the international border with Mexico.

It hosts a minor border crossing, an adobe sales outlet, a public school, a guest ranch, a general store with fuel pumps, a weekend bar, and a post office serving the ZIP Code of 85633.

[2] The name Sasabe is derived from the Native American language of the Tohono O'odham (formerly Papago) meaning "head valley".

[4] Sasabe is best known for its historic Rancho de la Osa guest ranch, formerly the headquarters of a three million acre (12,000 km2) Spanish land grant.

[7] Sasabe is seated on an arid, gently rolling sand-plain relieved only by scatter shrub trees and grass hummocks.