Marquis Sasaki Takayuki (佐々木 高行, November 26, 1830 – March 3, 1910) was a bureaucrat, government minister and court official in late Meiji period Japan.

He served the Yamauchi clan in several important posts, including kōri-bugyō (country magistrate) and ōmetsuke (inspector).

He also supported Sakamoto Ryōma in the Taisei hōkan movement to restore political power to the Emperor of Japan at the expense of the Tokugawa Shogunate.

During the Boshin War, he commanded the Kaientai, a paramilitary group of Tosa samurai youths, and occupied the Tokugawa magistrate's office at Nagasaki.

[3] He was also associated with Nishimura Shigeki in promoting patriotic education and emperor worship in the public school curriculum.