[1] During the Japanese occupation of the Dutch East Indies, Sastrodiredjo worked as a physician for sugar companies in Situbondo.

[1] In the Indonesian National Revolution, Sastrodiredjo served as Junior Minister of Health in the Republican government under Amir Sjarifuddin.

[2] After the war, he worked at the municipal health department of Surabaya and later became the assistant director of the city's public hospital,[2] while also lecturing at the faculty of medicine of Airlangga University.

[8] Following the 30 September movement and the ensuing purges against PKI, according to the U.S. Consulate in Surabaya, Sastrodiredjo had not been removed from his post by December 1965, although he was "staying quietly at home".

[3] Due to censorship of PKI-related symbolism, his portrait along with those of Moerachman would not be displayed by the Surabaya municipal government until the tenure of Tri Rismaharini in the 2010s.