Sauquoit Creek is a 17.0-mile-long (27.4 km)[2] river in New York, United States.

The creek flows eastward, then turns sharply and flows generally northward through the Sauquoit Valley to the Mohawk River, entering the river on the east side of Whitesboro.

[5] Flooding is common in the portion of Whitesboro along the creek, often causing road closures.

One of the most impactful floods occurred on the night of Halloween 2019, when residents were evacuated and houses were destroyed.

The stream is stocked annually approximately 6,000 yearling brown trout, in addition to 330 two-year-old fish.