[4] Lightfoot-Leon was born in Leiden, Netherlands[5] to English father Paul Lightfoot and Spanish mother Sol León, both dancers and choreographers, and grew up in The Hague.
[7] As a child, Lightfoot-Leon appeared in the projected background videos of her parents' ballet and contemporary dance productions, such as Silent Screen (2005)[8] and Stop-Motion (2014) at Lucent Danstheater in The Hague.
[11] Upon graduating from RADA in 2020,[12] Lightfoot-Leon was also featured in their project with Nederlands Dans Theater (NDT), She Remembers,[13] which was staged virtually.
For her performance in Hoard, she was awarded a Special Jury Mention at the 80th Venice International Film Festival.
In 2024, Lightfoot-Leon had a major role in the Paramount+ series The Agency, playing CIA field officer Daniela Ruiz Morata.