DeMelo missed her junior season because of a torn Achilles' tendon,[3] but she successfully returned to action as a senior, starting all 14 games.

[4] DeMelo made her professional debut on March 25, playing 11 minutes off the bench against the Houston Dash in Racing's second game of the 2022 NWSL Challenge Cup.

[6] DeMelo's first professional goal, a game-winning direct free kick against San Diego Wave FC on May 18, 2022, was featured on ESPN's SportsCenter Top 10.

[2][11][12][13] In September and October 2022, DeMelo received her first call-ups to the U.S. senior national team for friendlies against Nigeria, England, and Spain, but did not see any playing time.

[15] At the World Cup, DeMelo was in the starting lineup for the team's first two group stage matches, a 3–0 win against Vietnam and a 1–1 tie to the Netherlands.