The series stars Lennie James as Nelson "Nelly" Rowe, a down-and-out whose life is turned upside down when Jody, the estranged daughter he fathered thirteen years ago, mysteriously disappears.

He begins a determined quest to get to the bottom of things and find his daughter, lying, begging favours and stretching his friendships to the limit in the process.

Aside from James and Jones, Stephen Graham and Jason Flemyng as friends Melon and Tam are also credited as principal members of the cast.

The website's critics consensus reads, "Save Me will rescue viewers' evening with outstanding performances and an absorbing mystery that never ceases to dazzle with its revelations.

The website's critics consensus reads, "Save Me's second season overcomes the shortcomings of its first, deepening its characters and even finding a little levity in its harrowing tale.