The S.72 was a three-engine, high-wing cantilever monoplane with a fixed tailwheel landing gear.

Designed as a heavy bomber, the prototype was first flown in 1934 powered by three 410 kW (550 hp) Alfa Romeo licence-built Bristol Pegasus radial engines.

The Regia Aeronautica showed no interest in the aircraft as a heavy bomber and the prototype was used as a VIP transport.

After being demonstrated in China in 1935 the prototype was handed over to Generalissimo Chiang Kai-shek as a gift.

It is presumed that all the aircraft were destroyed in Japanese air raids in 1937.