It is situated 6 miles (10 km) south-west from Louth, on the A153 road, and within the Lincolnshire Wolds, a designated Area of Outstanding Natural Beauty.

In 1185, Roger de Maletoth gave a bovate, around 20 acres of land, at Scamblesby, to the Knights Templar.

[2] In 1507, the prebend of Scamblesby was held by Polydore Vergil, an Italian historian and priest, who had moved to England in 1502.

[4] In 1672, Herbert Thorndike, Canon of Westminster Abbey, left the 'lands and tenements' he owned in Scamblesby, to be held in trust, to provide a 'perpetual vicarage' for the local church.

[citation needed] In 2007 Scamblesby Church of England Primary School achieved examination grades higher than the local and the national average.