Nests are frequently constructed in shaded niches, often just inside of windows or vent openings, and it may take a female only a day to construct a cell requiring dozens of trips carrying mud.

Each mud cell contains one egg and is provided with several prey items.

Females of some species lay a modest average of 15 eggs over their whole lifespan.

Like other solitary wasps, Sceliphron species are not aggressive unless threatened.

Species such as Sceliphron curvatum are invasive in some parts of Europe, where they have been observed to rapidly increase their range in recent years.