Schio (Italian pronunciation: [ˈskiːo]) is a town and comune in the province of Vicenza (region of Veneto, northern Italy) situated north of Vicenza and east of the Lake Garda.

Schio is now an industrial town thanks to Alessandro Rossi, who founded the biggest Italian wool firm (Lanerossi) in the 19th century.

Rossi also arranged the building of houses, nurseries, schools, theatres and gardens for his workers.

Schio was called "Manchester of Italy", because it was the focal point of the northern wool trade like the British city.

After World War II, the Italian resistance movement committed the Schio massacre in a temporary prison building in July 1945, killing 54 inmates.